My .02 cents on Irish Wolfhounds. Their general nature, is not very aggressive. They "do" have the [size, weight & teeth]. To offer up a hard fight. But they are somewhat slow, because of their size.
Now, if you cross-breed one[wolfhound] with a smaller aggressive dog. With a bad-boy heritage. Then there is a better chance to have one that's packing some grit.
Any dog/hound, that's first on-scene. Who makes the mistake of not going immediately for the throat. Is in for some serious education, on a coyote. Let alone a large wolf.
Also, IMHO a coyote or wolf are both quicker in a fight. Than any coyote killin dog/hound, I've ever seen. Have you ever heard or read of a dog/hound running over 10 miles w/o stopping. Let alone 20-50 miles. That tells me of a coyote or wolf's endurance.
I have seen many Grey Wolves up close in pens. They were all massive in size[well over 100lbs].
The wolf, whom our two trail hounds caught & battled was very large. My Dad's large male Black-n-Tan weighed 110lbs. He was all grit. As well as the other hound. A Walker around 60lbs. Both dogs would plow head-on, right into a coyote. But they both needed some serious back-up on that big boy.