Although the 100grn rounds will probably work OK in a .243 I would actually suggest 80 or 75gr bullets in a .243win for no or minimal splashes and minimal pelt damage. I have only used a .243win for hunting coyotes with a centerfire rifle. These bullets are closer to the ideal weight for a .243 because you get better trajectory, and you can pick up the ammo fairly easily and not too expensively from Midway or Natchez Shooting supply. Look at the the federal blue box 80gr. soft points and the Hornady 70gr. HP's are I think the other one I buy when on sale for coyotes. They both have performed well for me, and I would use the soft points for deer as well at least inside 300yrds.
As for splashes, I think Chupa has the jist of what I believe on here already mentioned. If you get a light enough bullet and spin it fast enough it will just break apart from the centrifugal forces. I hear stories about how back in the 1960's or 70's there used to be a lot of problems with .223/5.56, AR's especially, having bullets tumble or tear apart, and from what I understand, it was solved with proper twist rates. Also, I have seen what .243win gamekings do at 80yrds on a deer. It eviscerated everything including the bullet. I butchered the whole deer with a little help, and I only found a few pieces of bullet jacket out of 3 bullets I put in the boiler maker! It also took a few minutes for the deer to realize he was dead. even though he had almost all his lung tissue, like I said, EVISCERATED!!! I still can't believe how long it took, but that is a different discussion entirely.