The 25-06 is a much better big game rifle than the 243 Win.
It is a great long range rifle for medium game, and predators.
There have been some improvements in the bullet selection.
For game, I prefer the 100 gr. Barnes TSX. It hits like the
Hammer of Thor, and has great weight retention. For predators,
the 85 gr. Nosler BT is just plain violent. The reads NOT
FUR friendly. But if one wants to dispatch predators, and
varmints, with extreme prejudice, this is your bullet.
The negatives of the 25-06 Rem. versus the 243 Win, is it
is a long action round, so that means a heavier rifle in
some cases, and due to barrel heating, this is not a colony
varmint rifle. The 243 Win, would be a better choice for
high round count shooting.
I have a friend that wanted a new "deer" rifle. I steered
him towards a Tikka, in 25-06 Rem. He was a 30-06 Sprg
fan previously. He took the leap of faith, and got the
Tikka, in 25-06. The first three deer he shot were
BANG flops. He was impressed. He hunts a small chunk of
land, so it is important for deer to drop quickly. He has
a much more confidence that this fast moving, hard hitting
25-06 will do that. For brush hunting, I have a BAR in 308
Win, but for open country shooting, my clear first choice is
the 25-06. It flies flat, and hits hard.
Squeeze