I have been a 22-250 fan for years. Several years back I bought one of the Whitaker Special Offer 8" twist Tikka rifles. I shot it with heavier bullets, and I found it to be ho-hum at best for hunting purposes. I got rid of it maybe 8 months ago.
In the future I'll stick with the "terrible" 14" twist factory twist rate and I'll shoot lead-tipped 55 grain spitzer bullets in it at very good speeds. That combo will kill anything I'd shoot with a 22-250, and do it extremely well at extended varmint/predator hunting ranges. Just like it has done for years.
If I need more bullet in a factory rifle for some reason, I'll get a 6MM Remington or a 243 Winchester, named as examples, to do what I want to do.
For heavier 22 caliber bullets, I stepped up to a 22-6MM Rem rifle/cartridge combination for long range coyotes. It or a 22-243 Win will shoot heavier bullets far better than a 22-250 will in terms of a flat trajectory.